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Piccirilli, Joseph A.
One or more keywords matched the following items that are connected to Piccirilli, Joseph A.
Item TypeName
Concept Substrate Specificity
Academic Article RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.
Academic Article A new metal ion interaction in the Tetrahymena ribozyme reaction revealed by double sulfur substitution.
Academic Article Aminoacyl esterase activity of the Tetrahymena ribozyme.
Academic Article Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli.
Academic Article Abortive products as initiating nucleotides during transcription by T7 RNA polymerase.
Academic Article The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
Academic Article Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome.
Academic Article Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage.
Academic Article The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
Academic Article A second divalent metal ion in the group II intron reaction center.
Academic Article General acid catalysis by the hepatitis delta virus ribozyme.
Academic Article The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins.
Academic Article Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.
Academic Article Linkage between substrate recognition and catalysis during cleavage of sarcin/ricin loop RNA by restrictocin.
Academic Article Functional identification of ligands for a catalytic metal ion in group I introns.
Academic Article Thermodynamic evidence for negative charge stabilization by a catalytic metal ion within an RNA active site.
Academic Article The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.
Academic Article Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry.
Academic Article Recognition of guanosine by dissimilar tRNA methyltransferases.
Academic Article Defining the catalytic metal ion interactions in the Tetrahymena ribozyme reaction.
Academic Article Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate.
Academic Article A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.
Academic Article General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.
Academic Article Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage.
Academic Article Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics.
Academic Article Enzyme transition states from theory and experiment.
Academic Article Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects.
Academic Article Synthesizing topological structures containing RNA.
Academic Article Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.
Academic Article Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State.
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